Our patients don’t have to travel far to get cutting-edge, quality cancer care. 他们的医生是他们的朋友和邻居. 没有比这更个性化的护理了.&,
琳达T. Vahdat，医学博士，MBA作为副局长， 琳达T. Vahdat，医学博士，MBA, is helping transform the face of research and patient care at 十大网赌平台推荐癌症中心, 破解金属在癌症中的作用是她成就的核心.
在这个Q中&A, she outlines her research journey from a high school science fair to her role in pivotal cancer drug development, 她是如何与病人建立伙伴关系的, and why she hopes to open the first metals in cancer institute at 十大网赌平台推荐卫生.
You recently celebrated one year at 十大网赌平台推荐癌症中心 – congratulations! 是什么让你进入肿瘤学领域的?
Vahdat: 从一开始，我就对癌症很感兴趣. My high school science fair project on radiation biology was a turning point. 我看到有很多工作要做. 但我也被癌症患者所吸引. 他们通常都很投入. You can achieve a lot when you share the goal of getting rid of cancer and maintaining a healthy lifestyle. 你们建立了一种特殊的关系.
我试着告诉我的病人他们的选择, 发生了什么, 该怎么做才能让他们重获控制感. 知识有助于减少焦虑.
琳达T. Vahdat，医学博士，MBA
你在黎巴嫩和曼彻斯特都能看到病人. What observations can you share about 十大网赌平台推荐癌症中心 曼彻斯特 specifically and 十大网赌平台推荐癌症中心 overall?
如何阻止癌症的扩散
二十年前， 我们在乳腺癌方面的工作 began with a simple question, “how can tumors lie dormant for years and then return?“在这段时间里，我们已经确定了肿瘤生长所需的条件. That has led to the discovery that metals, specifically copper, allow cancer to come back and spread.
We focused on breast cancer patients who were at an increased risk of tumor recurrence and created a copper depletion pill. 我们与科学家和临床医生合作，开展了一项临床试验. 试验发现我们的药很安全副作用很小. 而且价格实惠.
另外, the pill successfully changed tumor and patient-related factors so metastases couldn't occur. We found that this was an especially effective approach in a hard-to-treat cancer called triple negative breast cancer. Detailed scientific studies confirmed that we were removing the framework tumors often hijack to spread. 的se successes have led to more research to identify which patients benefit most from this treatment strategy.
We are really excited to open a randomized phase II study of copper depletion in triple negative breast cancer patients. 我们预计这项试验将于2023年春季在十大网赌平台推荐开始.
——琳达·T. Vahdat，医学博士，MBA
Vahdat: 的 曼彻斯特 团队具有令人难以置信的凝聚力，是一台“运转良好的机器”." We have a great group of specialized care providers meeting to brainstorm and share knowledge on complex cancer cases. 的ir collaboration is bringing everyone together to improve therapeutic and supportive care in southern New Hampshire and across the entire 十大网赌平台推荐卫生 system.
在治疗方面，我们正在开放 临床试验. What is unique about 临床试验 is that they provide patients with early access to therapeutics that eventually might be FDA approved. 通过我们，病人无需前往波士顿数小时就能得到这种治疗.
对于支持性护理，我们正在帮助患者为自己辩护. Stoic New Englanders might find it hard to acknowledge when they are not feeling well—whether from disease or from side effects of therapy. But patients who come armed with information are completely engaged and often achieve the best results.
有时候你需要跳出你的世界去思考 减少副作用的策略. 冷帽可以减少脱发. 例如，尼古丁贴片可以帮助缓解手脚肿胀. Cold mittens and booties can prevent numbness and tingling in the fingers and toes. We also have strategies for nail changes, eyelash loss, impacts to taste buds, and hot flashes.
我试着告诉我的病人他们的选择, 发生了什么, 该怎么做才能让他们重获控制感. 知识有助于减少焦虑.
包括你自己对金属的研究, which emerging cancer research and technology are you most excited about and why?
Vahdat: I’d like to eventually see the first metals in cancer institute at 十大网赌平台推荐卫生. 现在, I’m working on a copper depletion drug and we are starting a clinical trial to test its effectiveness in high risk for recurrence triple negative breast cancer. We know that tumors hijack normal infrastructure to spread and that metals are important for that process. Our idea is that copper depletion can interrupt the hijacking process and stop metastasis.
我也对乳腺癌免疫疗法的未来感到兴奋. Dartmouth scientists are contributing to our fund of knowledge in that area so that we can better understand how to use immunotherapy to care for our patients. 另一个领域是抗体药物偶联物(adc)，这也是一个大热门. ADC本质上是一种针对肿瘤的智能炸弹. I helped bring the first ADC for triple negative breast cancer to market, Trodelvy® (sacituzumab). 从那时起，adc越来越受欢迎. One ADC that we are very excited to bring to 十大网赌平台推荐卫生 targets the epidermal growth factor receptor (EGFR) gene. Since twenty-five to thirty percent of all triple negative breast cancers have this mutation, 我们希望这将帮助我们的病人. 我们正在开始可能是第一次 药物试验 十大网赌平台推荐健康中心的病人.
在十大网赌平台推荐癌症中心，临床试验的未来会是什么样子?
Vahdat: We have access to new therapeutics unavailable in Boston and New York because 临床试验 能快速通过我们的系统吗. We’re doing the work to ensure a patient can join a clinical trial when they need it.
Ultimately, our patients don’t have to travel far to get cutting-edge, quality cancer care. 他们的医生是他们的朋友和邻居. 没有比这更个性化的护理了.
琳达T. 医学博士，工商管理硕士， 是乳腺肿瘤学家吗, section chief of Medical Oncology and Deputy Director of 十大网赌平台推荐癌症中心. 在她的学术角色中, she serves as the Milham Professor and Professor of Medicine at Dartmouth’s Geisel School of Medicine. Vahdat has more than 20 years of experience in caring for people with breast cancer, 特别关注三阴性乳腺癌, 转移性乳腺癌和复发风险高的乳腺癌. 她参与了身份鉴定工作, 概念化, design and conduct of Phase 0 through III 临床试验 of new therapies in high-risk adjuvant and metastatic breast cancer patients since 1994. She has led efforts in FDA approval of three drugs active in metastatic breast cancer and continues to initiate new breast cancer 临床试验.